Antibacterial Resistance. The Challenge of Modernity
نویسندگان
چکیده
Antimicrobial resistance is considered by WHO as one of the most important threats to public health in twenty-first century. According forecasts, 2025, many first-line antimicrobials will lose their effectiveness and «post-antibiotic era» begin. Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp. representatives genus Mycobacterium are classified American Society Infectious Diseases microorganisms that play a predominant role development infections associated with medical care leading fatal consequences. The review highlights mechanisms antibiotic variants microbial antibiotics. Knowledge molecular formation allows us develop strategic directions for overcoming it. search new ways prevent overcome pathogens antibiotics an extremely task modern science. hybrid chemical compounds various specific effects presented. use main active factor bacterial virus, endolysin, both its pure form part homodimers, example, lysoprotein, which complex endolysin human immunoglobulins, promising. Phage therapy future personalized phage requires creation library or bank phages.
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ژورنال
عنوان ژورنال: ??????????? ? ????????????
سال: 2023
ISSN: ['1991-7740']
DOI: https://doi.org/10.37489/0235-2990-2023-68-3-4-66-75